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research on the matter...from the linked paper on potential biological causes for Gender Dysphoria...
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Plain Language Summary

Gender identity is an important issue in society, yet its causative mechanism is poorly understood. The main anatomical differences between males and females are the genitalia and the brain. This paper reviewed the literature to explore the link between genetic influences and brain development, and their impact on gender identity. Investigating these developmental mechanisms could lead to advances in the understanding of gender dysphoria, a condition whereby an individual’s gender and biological sex are mismatched. Exploring the biochemical development of the genitalia highlights the differences between males and females, notably how testosterone elicits the pathways of male development in an embryo. When research has been conducted in people with Androgen Insensitivity Syndrome, a condition where the testosterone receptor is mutated and faulty, and thus cannot function, gender dysphoria is observed as the body is genetically male but anatomically female. It is known that the structure of male and female brains differs; it is found that people with gender dysphoria have a brain structure more comparable to the gender to which they identify. The review of the literature suggests that there is a disparity between the brains of those who identify differently to their assigned gender at birth, highlighting a multifactorial underpinning of the gender identity. Further research is required to shed light on the molecular mechanism of this, allowing for greater education and understanding of this scientific and social phenomenon.
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In addition to the studies on Causation...there are also many studies on the value of Gender Surgeries as a means of providing a more satisfactory life for those afflicted with Gender Dysphoria...as well as fewer suicides. I've posted on this before, with information showing that the relatively few who choose surgeries have very high 'Non-Regret' outcomes...i.e. MUCH BETTER than therapists endeavoring to "Talk them out of it".

Bottom Line...Science is on the side of Progress in treating such fellow human beings.


Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC7415463/