it was with the Boston smallpox outbreak in 1901.
Nearly everyone on this board has gotten vaccinated...I'm guessing that the necessary majority in this country will as well, once their mandated choices are limited to a) saving lives and returning to normal activity, or b) more sickness, deaths and impeded economic progress.
Link: https://constitutioncenter.org/interactive-constitution/blog/on-this-day-the-supreme-court-rules-on-vaccines-and-public-health