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....here's a summary response to the question of whether HCQ, in high doses, can cause cardiac problems...
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AI Overview
Yes, high doses of hydroxychloroquine (HCQ) can result in cardiac problems, especially with acute overdose or long-term use at higher doses.
Potential cardiac problems include:
QT prolongation: This is a lengthening of the QT interval on an electrocardiogram, which can increase the risk of developing dangerous arrhythmias like torsades de pointes.
Ventricular tachycardia and fibrillation: These are types of irregular heartbeats that can be life-threatening.
Cardiomyopathy: This is a condition where the heart muscle becomes thickened, stretched, or stiffened, impairing its ability to pump blood effectively. It can eventually lead to heart failure.
Heart failure: A condition where the heart cannot pump enough blood to meet the body's needs.
Conduction abnormalities: Disruptions in the heart's electrical system, such as atrioventricular (AV) block or bundle branch block.
The risk of these problems increases with higher doses and prolonged use. Additionally, combining HCQ with other medications that can also prolong the QT interval, such as the antibiotic azithromycin, further increases the risk.
It's important to note that hydroxychloroquine has a long half-life, meaning it stays in the body for an extended period, which allows for potential accumulation with repeated dosing, even at relatively low doses.
While hydroxychloroquine is prescribed for malaria treatment, it's crucial to follow your doctor's orders carefully regarding dosage and duration to minimize the risk of cardiac and other adverse effects. If you're taking hydroxychloroquine and experience any symptoms like irregular heartbeats, dizziness, or fainting, seek immediate medical attention.
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Given that no RCTs showed a benefit from HCQ+...and that some patients could experience cardiac problems from inappropriate doses...it was wise for the FDA and WHO to cancel their EUA for this potential treatment.

Also, no one ran a trial to demonstrate HCQ+'s ineffectiveness...no one ran an RCT according to Dr. Risch's protocol...sorry, but that's on him and his fellow proponents for not designing and conducting one....it's not the FDA's responsibility. I'm trying to be as charitable toward you as I can...someday, I'm hoping you'll get it...the "Sponsors" of HCQ+ have never provided evidence that their drug combo works in the way they said it should be.

btw, what would you do or say if I read Dr. Risch's paper?...what difference would it make for HCQ+?