Several scenes but most notably when Matthew McConaughey's character gets back to the ship and he's told he has spent the equivalent of 23 Earth years on a planet. He then sits and watches all the videos his kids have sent him from Earth while he's been away. He realizes they've grown up without him. His son has a kid, his daughter is pissed because he promised he'd come back and he hasn't. He's missed out on all the normal stuff we fathers take for granted. Gut wrenching every time.