Holding off on the TPP (at least until we can review it more carefully - you must admit that Obama-negotiated deals don't go well for us usually).
limiting the uncontrolled illegal immigration will take a tremendous financial burden off of our medical system as well as other sectors.
Having a real sit down with Mexico on what we expect from them as a neighbor is another really big thing imo. Why are these poor refugees running here? We have to address the issue of Mexico taking the easy way out and dumping it's own responsibilities onto us. thy are a corrupt govt, and they will respond to the threat of losing their personal income streams wrt trade deals with the US.
until mexico is changes, people will continue to flow to us until our conditions get as bad as theirs..