What is the science on people who believe they were born with the wrong genitalia? What is their chromosomal makeup? Do a person's chromosomes determine their gender identity? That's the denial. It then goes off the charts when someone further argues that gender and sex are different, despite the fact that every single time a man identifies as "transgender," he chooses to make himself like a woman, and vice versa. Gender and sex are one and the same and the science on what determines your sex was long ago established.
Believing that you were "meant" to be the opposite sex is no less delusional than believing you were "meant" to be a different race or to be disabled, both of which have now become things in the midst of "trans-mania," as some have correctly identified it.
Indulging in the fixations of people struggling with this condition does them no favors. They self-harm and suicide at astronomical rates, across cultures, which suggests that environment does not explain these astronomical rates. In fact, the rates remain astronomical for those who have the surgery, which also undercuts the argument that the self-harm and suicide rates can be attributed to harassment and lack of acceptance.