On the Weightlifting side, Option A is far more sustainable than Option B. If you're in your 30's and drug-free, Option B could be performed about once every 7 to 10 days. Otherwise, you're constantly going to be in repair phase and never fully recovered, meaning you will not grow and strength won't improve. And you are bound to get injured. Option B is fine for high-schoolers and college students preparing for a sport. That's about it.
Running-wise, this depends entirely on your goals and training schedule. If you have any cardiovascular or serious weight training scheduled within the 3 days following this run, Option B is terrible. There is significant recovery from a training session like that before you can perform again, so if you have training of any kind that you want to do within 72 hours, you can forget it.