It covers the entire infection process in considerable, but fairly easy to understand, detail...in it you'll find this section that deals with Hydroxychloroquine
"The virus’s speedy entry using TMPRSS2 explains why the malaria drug chloroquine didn’t work in clinical trials as a COVID-19 treatment, despite early promising studies in the lab10. Those turned out to have used cells that rely exclusively on cathepsins for endosomal entry. “When the virus transmits and replicates in the human airway, it doesn’t use endosomes, so chloroquine, which is an endosomal disrupting drug, is not effective in real life,” says Barclay."
This is essentially what I was trying to communicate with you earlier (re: TMPRSS2)...now you know the full story...glad to help...
P.S. You should know by now that "Nature" is one of the most respected sources of medical information.
Link: https://www.nature.com/articles/d41586-021-02039-y