Clemson plays quarters about 50% of the time in their base defense. They are very comfortable with 2 safety looks.
I can't see a situation where Clemson looks at ND's run game and say, "they will not only be able to gash is with 7 in the box but also ND will be patient in doing so".
Clemson is going to rely on their front 7 to win in the run game and make it harder for Book to find lanes.
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