That 2004 offense was all but unstoppable.
All of their players were very well schooled in the pro-style offensive scheme, and there were some really complex blocking schemes for the offensive line, TE's, and RB's that would have been all but impossible for most teams to do. The best way I can describe his offense is a modified Air Raid attack that incorporates more ball control (no hurry up / no huddle).
When you have 1st and 2nd round draft picks at almost every offensive position, it's certainly one of the best schemes, but its learning curve makes it very difficult to implement, especially if you want your freshmen and sophomores to play. He tried doing that at Hawaii, and flopped pretty badly, since the players were nowhere near the caliber require for it.