UHND.com - Notre Dame Football, Basketball, & Recruiting

(no message)

(no message)

The Biden WH and Fauci et all were submarining all scientific discussion on the topic.

HCQ had a niche - esp when COVID first was upon us.

You’re asking people with no expertise and limited intellect to understand something they can’t (they don’t know how to review articles), and more importantly, they have a political motivation to deny this.


Link: https://www.sciencedirect.com/science/article/pii/S0002934320306732

(no message)

a measure of how credible it is...by contrast, the "New England Journal of Medicine" NEJM's IF is 74.699...in point of fact, the AJM doesn't make the Top 20 journals...here is what the NEJM had to say about HCQ...(dated Nov. 19, 2020...long after Dr. Risch's claims were made.
-------------------
Abstract

BACKGROUND
Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials.

METHODS
In this randomized, controlled, open-label platform trial comparing a range of possible treatments with usual care in patients hospitalized with Covid-19, we randomly assigned 1561 patients to receive hydroxychloroquine and 3155 to receive usual care. The primary outcome was 28-day mortality.

RESULTS
The enrollment of patients in the hydroxychloroquine group was closed on June 5, 2020, after an interim analysis determined that there was a lack of efficacy. Death within 28 days occurred in 421 patients (27.0%) in the hydroxychloroquine group and in 790 (25.0%) in the usual-care group (rate ratio, 1.09; 95% confidence interval [CI], 0.97 to 1.23; P=0.15). Consistent results were seen in all prespecified subgroups of patients. The results suggest that patients in the hydroxychloroquine group were less likely to be discharged from the hospital alive within 28 days than those in the usual-care group (59.6% vs. 62.9%; rate ratio, 0.90; 95% CI, 0.83 to 0.98). Among the patients who were not undergoing mechanical ventilation at baseline, those in the hydroxychloroquine group had a higher frequency of invasive mechanical ventilation or death (30.7% vs. 26.9%; risk ratio, 1.14; 95% CI, 1.03 to 1.27). There was a small numerical excess of cardiac deaths (0.4 percentage points) but no difference in the incidence of new major cardiac arrhythmia among the patients who received hydroxychloroquine.

CONCLUSIONS
Among patients hospitalized with Covid-19, those who received hydroxychloroquine did not have a lower incidence of death at 28 days than those who received usual care. (Funded by UK Research and Innovation and National Institute for Health Research and others; RECOVERY ISRCTN number, ISRCTN50189673. opens in new tab; ClinicalTrials.gov number, NCT04381936. opens in new tab.
------------------------

I do know how to read...as well as judge where to get the best information...also, if I have a question on a subject like HCQ, I have a family member who is a certified expert in the field of Infectious Diseases and who I can go to with questions...(Baron is not certified in ID)...I did ask about HCQ and was given this response..."Hydroxychloroquine is totally debunked. Not helpful and is literally a joke in the ID community."

This is another example of Baron being frustrated by the fact that someone else can always have the upper hand in any discussion regarding COVID-19, and probably goes a long way toward explaining why he chose to "Ignore" me...too bad, Baron...you need to face reality...


Link: https://www.kolabtree.com/blog/top-20-medical-journals-for-physicians-to-publish-in/

(no message)

"HCQ is also a zinc ionophore that conveys zinc intracellularly to block the SARS-CoV-2 RNA-dependent RNA polymerase, which is the core enzyme of the virus replication."

This is exactly what Dr. Zelenko has said. He described zinc as the bullet and HCQ as the gun. And also interestingly was the premise that RCTs were expected to be conducted to affirm or deny its effectiveness. Unfortunately, no parallel RCT was ever conducted, per Dr. Risch.

data to support using it as an option with those patients meeting criteria back then. But the Dem WH and governors banned its use which was absolutely unprecedented. They banned a drug with promise, low cost, and wide availability and no other options present at the time.

The politicization of American medicine by the Dems and it very likely cost lives for those in the drug’s specific niche of treatment. They wanted the shut down to hurt Trump. Also, the drug was linked to Trump when he received it and then advocated for it (he advocated for its use more widely than what it actually should be used for - which you’d expect from a non doctor- same ignorance as Jim or tyrone or whomever else your discussing this with on this board.

"Thumbs Down" on HCQ (see link)...no Dems in the UK, Germany, France, Japan...etc., etc...just a lot of very good medical professionals...

Link: https://www.medicalnewstoday.com/articles/who-strongly-against-hydroxychloroquine-use-for-covid-19-prevention

Is understandable to anyone...apparently to anyone who's not Chris, Jim and Tyrone. I'll give Conor a pass as he really hasn't weighed in on this for a long time.

(no message)

(no message)

who am I to stop you.

By now, even you have to question the narrative that HCQ+ doesn't work.

Ponder this, if you will. The only RCTs showing it doesn't work are those conducted in the way it's not supposed to be used. There are no (to Dr. Risch's knowledge) RCTs showing it doesn't work the way it's supposed to be used. All the credible observational trials of the way it's supposed to be used show it works.

Doesn't it at least give you pause how the Great Fauchino used these criteria to say it doesn't work in vulnerable patients given the drug combo within 5 days of symptom onset? And please, no more linking to two-year-old articles with non-knowledgeable "experts" who also pointed to non-parallel studies to "debunk" Dr. Risch.

disappointing, I know, for Dr. Risch...he, and you, need to learn from the experience and move on.

Even you acknowledge that PAXLOVID works exceptionally well...be grateful that we have medical scientists and organizations that 'designed' it well and were able to get into the public's hands quickly.

Now, onto 2023...Happy New Year!

Show us your data on an RCT that used HCQ + zinc + azithromycin on vulnerable demographic patients who were given this combo within 5 days of symptom onset, and showed this combo was not proven to be effective in reducing hospitalizations and deaths from Covid.

btw, while you're at it, ask him/her for something that will cure your "Thin Skin" ;-)

Mark is beating you into submission and I'm here for it.

(no message)

You did so because HCQ brought a message of hope (whether that was reasonable or not) and your immediate response was to dismiss it. You dismissed it not because you had evidence it should be dismissed, but because you were rooting for death and despair.

I'm just passing the word along to you and Mark...Capice?

btw, for what it's worth, I agree with them ;-)

You were rooting for death and despair and in doing so you boxed yourself into a position that you cant defend. Mark has had you by the balls all this time. You're either too blinded by bias, too stupid, or too terrible a person to admit it.

For the millionth time, the studies they are relying on showing HCQ+ to be ineffective are in no was parallel with the way it's supposed to be used. But then the false report came out in The Lancet about cardiac risks and all RCTs were halted at that point, so yes, they could truthfully say there were no RCTs showing HCQ+ to be effective.

This is a complete failure from our supposed esteemed health organizations and leaders that they ignored the reams of credible observational data, all because they followed whatever Fauci told them was "the science."

The worse covid got, the worse it was for Trump. They were rooting for death and despair, not for solutions.

These were the same assholes that said they wouldn't take the Trump vaccine, but turned around and mandated the Trump vaccine as soon as Biden took office.

It's not about the science. It was never about the science. It was simply about finding a way to hurt Donald Trump.

change their minds, I'll read Dr. Risch's paper...Deal?

(no message)

Why do you keep saying this? No, it didn't work by itself or on hospitalized patients, the only studies naysayers point to. But it did work when combined with zinc and azithromycin used within 5 days of symptom onset, studies naysayers (including Saint Fauchino) completely ignore.

Do you really lack the capacity to use any sort of basic logic?

a prescription if they test positive for COVID...good luck with that ;-).

Falsely telling people it didn't work.

(no message)

But in this case, I'm relying on the incredible work of Dr. Risch, who like Baron, understands the science.

You aren't the whole horse, just the ass. And it's only your brain that's dead.

Jim and Ty and incredible liars. There is a 46% chance that you've already convinced them, but theyre not willing to give you the satisfaction. Just call them shitbirds and move on.

(no message)

(no message)

(no message)