my play book would have at least 25 plays from differing two back sets that I would run over and over until every possible defensive reaction was accounted and counter-acted, much as our coach did for our undefeated high school team. When you have an advantage, use it. That does not mean abuse it, just use your players that do things better than any others. It may take the slot away, but one of them can slip out, or stay in as a blocker for pass blocking or sweeps. Use your advantages....and there are two really big ones.
But that window may be gone. Nevertheless, those two guys are still on the roster and still have elite skills. Don't let them rot!!!