Earlier in the 2012 season, Michigan State was -5 when it hosted ND.
Going further back, Utah was -5.5 when it took on 4-5 Notre Dame (coming off the Tulsa loss) during Brian Kelly's first season in 2010. Utah had been ranked #6 and just suffered its first loss to #4 TCU.
More recently, LSU was -7 in the 2014 Music City Bowl.