If you don't have a powerful nose tackle, and larger defensive ends who can reasonably catch up to a running back, then it's an exercise in futility.
It was a different matter entirely, back when we had Big Louis "Irish Chocolate" Nix at nose tackle, a nearly 300 lb Stephon Tuitt at one defensive end, and a 300 lb Kapron Lewis-Moore at the other defensive end position. Each of those guys could command a double team, leaving one of them able to take advantage of a one on one matchup, or it would take away the opposing offense's ability to send out the tight end in a pass play.