The Zellars run against Purdue was sheer beauty and beast at the same time. But this one ain't too bad for 2nd place: https://www.youtube.com/watch?v=2ZDZ6v2fzeo
However, I think Brock Spack's look of utter hopelessness was the best part of the 2005 game!!!
I'm sure there are a lot of older ones too, but when I think of Purdue, those are the two I think of (other than Davies complete incompetence in '99)